Cdc20 associates with the kinase aurora2/Aik.

  title={Cdc20 associates with the kinase aurora2/Aik.},
  author={Dawn C. Farruggio and Fiona M. Townsley and Joan V. Ruderman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={96 13},
Cdc20/fizzy family proteins are involved in activation of the anaphase-promoting complex/cyclosome, which catalyzes the ubiquitin-dependent proteolysis of cell cycle regulatory proteins such as anaphase inhibitors and mitotic cyclins, leading to chromosome segregation and exit from mitosis. Previous work has shown that human Cdc20 (hCdc20/p55CDC) associates with one or more kinases. We report here that Cdc20-associated myelin basic protein kinase activity peaks sharply in early M phase… CONTINUE READING