Cdc20: a WD40 activator for a cell cycle degradation machine.

  title={Cdc20: a WD40 activator for a cell cycle degradation machine.},
  author={Hongtao Yu},
  journal={Molecular cell},
  volume={27 1},
Cdc20 is an essential cell-cycle regulator required for the completion of mitosis in organisms from yeast to man and contains at its C terminus a WD40 repeat domain that mediates protein-protein interactions. In mitosis, Cdc20 binds to and activates the ubiquitin ligase activity of a large molecular machine called the anaphase-promoting complex/cyclosome (APC/C) and enables the ubiquitination and degradation of securin and cyclin B, thus promoting the onset of anaphase and mitotic exit. APC/C… CONTINUE READING
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