Cdc2-mediated phosphorylation of the gap junction protein, connexin43, during mitosis.

@article{Kanemitsu1998Cdc2mediatedPO,
  title={Cdc2-mediated phosphorylation of the gap junction protein, connexin43, during mitosis.},
  author={Martha Y. Kanemitsu and WenG. Jiang and Walter Eckhart},
  journal={Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research},
  year={1998},
  volume={9 1},
  pages={13-21}
}
As cells enter mitosis, gap junctional communication with neighboring cells decreases (H. Xie et al., J. Cell Biol., 137: 203-210, 1997). Phosphorylation of the gap junction protein, connexin43 (Cx43), has been implicated in reducing junctional permeability. Cx43 contains p34cdc2 phosphorylation consensus sites in its COOH-terminal region. Accordingly, we examined the role of p34cdc2/cyclin B in Cx43 phosphorylation. Purified p34cdc2/cyclin B, or p34cdc2/cyclin B complex immunoprecipitated from… CONTINUE READING

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The connexin 43 C-terminus: A tail of many tales.

Biochimica et biophysica acta. Biomembranes • 2018
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