Cdc2 as prognostic marker in stage UICC II colon carcinomas.

@article{Meyer2009Cdc2AP,
  title={Cdc2 as prognostic marker in stage UICC II colon carcinomas.},
  author={Alexander Meyer and Susanne Merkel and Wolfgang Michael Brueckl and Vera Simone Schellerer and Claus Wilhelm Schildberg and Valentina C{\^a}mpean and Werner Hohenberger and Roland Croner},
  journal={European journal of cancer},
  year={2009},
  volume={45 8},
  pages={1466-73}
}
PURPOSE Cyclin-dependent kinase 2 (cdc2) controls the G2-M checkpoint and, therefore, the entrance of cells into mitosis. It might play a crucial role during tumour progression in colon carcinomas (CCA). Thus, the prognostic value of cdc2 expression and connected markers relevant for proliferation and apoptosis has to be evaluated. EXPERIMENTAL DESIGN Punch biopsies from the tumour centre and the invasion front of 0.6mm diameter from 392 CCA stage UICC II-IV were integrated in 14 recipient… CONTINUE READING

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