Cdc2 activation: the interplay of cyclin binding and Thr161 phosphorylation.

Abstract

The mitotic kinase cdc2 must bind to a regulatory subunit--a cyclin--to be active. Cyclin binding controls the timing of activation of the kinase subunit, by modulating its interaction with upstream regulatory enzymes, and it also determines subcellular localization and substrate specificity. In this article, I summarize our present knowledge of the… (More)

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@article{Draetta1993Cdc2AT, title={Cdc2 activation: the interplay of cyclin binding and Thr161 phosphorylation.}, author={Giulio Francesco Draetta}, journal={Trends in cell biology}, year={1993}, volume={3 9}, pages={287-9} }