Cdc14B depletion leads to centriole amplification, and its overexpression prevents unscheduled centriole duplication

Abstract

Centrosome duplication is tightly controlled in coordination with DNA replication. The molecular mechanism of centrosome duplication remains unclear. Previous studies found that a fraction of human proline-directed phosphatase Cdc14B associates with centrosomes. However, Cdc14B's involvement in centrosome cycle control has never been explored. Here, we show… (More)
DOI: 10.1083/jcb.200710127

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@article{Wu2008Cdc14BDL, title={Cdc14B depletion leads to centriole amplification, and its overexpression prevents unscheduled centriole duplication}, author={Jun Wu and Hyekyung Cho and David Rhee and Dabney Johnson and John R. Dunlap and Yie Liu and Yisong Wang}, journal={The Journal of Cell Biology}, year={2008}, volume={181}, pages={475 - 483} }