Cdc13 at a crossroads of telomerase action

  title={Cdc13 at a crossroads of telomerase action},
  author={Dmitri Churikov and Yves Corda and Pierre Luciano and Vincent G{\'e}li},
  booktitle={Front. Oncol.},
Telomere elongation by telomerase involves sequential steps that must be highly coordinated to ensure the maintenance of telomeres at a proper length. Telomerase is delivered to telomere ends, where it engages single-strand DNA end as a primer, elongates it, and dissociates from the telomeres via mechanism that is likely coupled to the synthesis of the complementary C-strand. In Saccharomyces cerevisiae, the telomeric G-overhang bound Cdc13 acts as a platform for the recruitment of several… CONTINUE READING
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