Cdc 42 downregulates MMP-1 expression by inhibiting the ERK 1 / 2 pathway

  title={Cdc 42 downregulates MMP-1 expression by inhibiting the ERK 1 / 2 pathway},
  author={Christophe F. Deroanne and Delphine Hamelryckx and Theodore T. Ho and Charles Lambert and Philippe Catroux and Charles Maurice Lapiere and Betty V. Nusgens},
Interactions between cells and the extracellular matrix (ECM) components are primarily mediated through receptors of the integrins family (Hynes, 1992). Engagement of integrin triggers the assembly of focal adhesions and induces the reorganization of the cytoskeleton and the activation of various signalling cascades that culminate in the control of cell proliferation, survival, differentiation and gene expression (Danen et al., 1998). This includes the expression of genes coding for ECM… CONTINUE READING
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  • C. A. Sledz, M. Holko, M. J. de Veer, R. H. Silverman, B. R. Williams
  • Nat . Cell Biol
  • 2003
Highly Influential
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  • D. E. Ingber
  • 2002
1 Excerpt

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