CdGAP Associates with Actopaxin to Regulate Integrin-Dependent Changes in Cell Morphology and Motility

@article{Lalonde2006CdGAPAW,
  title={CdGAP Associates with Actopaxin to Regulate Integrin-Dependent Changes in Cell Morphology and Motility},
  author={David P Lalonde and M. Grubinger and Nathalie Lamarche-Vane and C. Heath Turner},
  journal={Current Biology},
  year={2006},
  volume={16},
  pages={1375-1385}
}
BACKGROUND Integrin signaling, stimulated by cell adhesion to the extracellular matrix, plays a critical role in coordinating changes in cell morphology and migration. The requisite remodeling of the cytoskeleton is controlled by the Rho family of small GTPases, which are, in turn, regulated via activation by guanine-nucleotide exchange factors (GEFs) and inactivation by GTPase-activating proteins (GAPs). However, the mechanisms contributing to the precise spatial and temporal regulation of… CONTINUE READING

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