Cd59a deficiency in mice leads to preferential innate immune activation in the retinal pigment epithelium–choroid with age

@article{Herrmann2015Cd59aDI,
  title={Cd59a deficiency in mice leads to preferential innate immune activation in the retinal pigment epithelium–choroid with age},
  author={Philipp Herrmann and Jill A. Cowing and Enrico Cristante and Sidath E. Liyanage and Joana Ribeiro and Yana{\'i} Dur{\'a}n and Laura Abelleira Hervas and L{\'i}via dos S. Carvalho and James W B Bainbridge and Ulrich F. O. Luhmann and Robin R Ali},
  journal={Neurobiology of Aging},
  year={2015},
  volume={36},
  pages={2637-2648}
}
Dysregulation of the complement system has been implicated in the pathogenesis of age-related macular degeneration. To investigate consequences of altered complement regulation in the eye with age, we examined Cd59a complement regulator deficient (Cd59a(-/-)) mice between 4 and 15 months. In vivo imaging revealed an increased age-related accumulation of autofluorescent spots in Cd59a(-/-) mice, a feature that reflects accumulation of subretinal macrophages and/or microglia. Despite this… CONTINUE READING