Cd40–Cd40 Ligand Interactions in Vivo Regulate Migration of Antigen-Bearing Dendritic Cells from the Skin to Draining Lymph Nodes

Abstract

Whereas CD40-CD40 ligand interactions are important for various dendritic cell (DC) functions in vitro, their in vivo relevance is unknown. We analyzed the DC status of CD40 ligand -/- mice using a contact hypersensitivity (CHS) model system that enables multiple functions of DCs to be assessed in vivo. Immunohistochemistry of skin sections revealed no… (More)

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@article{Moodycliffe2000Cd40Cd40LI, title={Cd40–Cd40 Ligand Interactions in Vivo Regulate Migration of Antigen-Bearing Dendritic Cells from the Skin to Draining Lymph Nodes}, author={Angus M. Moodycliffe and Vijay K. Shreedhar and Stephen E. Ullrich and Jeffrey P. Walterscheid and Corazon D. Bucana and Margaret L. Kripke and Leopoldo Flores-Romo}, journal={The Journal of Experimental Medicine}, year={2000}, volume={191}, pages={2011 - 2020} }