Cd2+-induced swelling-contraction dynamics in isolated kidney cortex mitochondria: role of Ca2+ uniporter, K+ cycling, and protonmotive force.

Abstract

The nephrotoxic metal Cd(2+) causes mitochondrial damage and apoptosis of kidney proximal tubule cells. A K(+) cycle involving a K(+) uniporter and a K(+)/H(+) exchanger in the inner mitochondrial membrane (IMM) is thought to contribute to the maintenance of the structural and functional integrity of mitochondria. In the present study, we have investigated… (More)

Topics

7 Figures and Tables

Cite this paper

@article{Lee2005Cd2inducedSD, title={Cd2+-induced swelling-contraction dynamics in isolated kidney cortex mitochondria: role of Ca2+ uniporter, K+ cycling, and protonmotive force.}, author={Wing-kee Lee and Malte Spielmann and Ulrich Bork and Frank Th{\'e}venod}, journal={American journal of physiology. Cell physiology}, year={2005}, volume={289 3}, pages={C656-64} }