Ccr6 Is Dispensable for the Development of Skin Lesions Induced by Imiquimod despite its Effect on Epidermal Homing of IL-22-Producing Cells.

@article{Cochez2017Ccr6ID,
  title={Ccr6 Is Dispensable for the Development of Skin Lesions Induced by Imiquimod despite its Effect on Epidermal Homing of IL-22-Producing Cells.},
  author={Perrine M Cochez and Camille Michiels and Emilie Hendrickx and Nicolas Dauguet and Guy Warnier and Jean-Christophe Renauld and Laure Dumoutier},
  journal={The Journal of investigative dermatology},
  year={2017},
  volume={137 5},
  pages={
          1094-1103
        }
}
Expression of the chemokine receptor Ccr6 is shared by most IL-22-producing cells, and Ccr6-deficient mice showed decreased IL-22 production and skin inflammation upon IL-23 intradermal injections. To determine whether this observation might be extended to another psoriasis model, we applied imiquimod on Ccr6-deficient mice. Although epidermal IL-22… CONTINUE READING