Ccr4-not complex mRNA deadenylase activity contributes to DNA damage responses in Saccharomyces cerevisiae.

@article{Traven2005Ccr4notCM,
  title={Ccr4-not complex mRNA deadenylase activity contributes to DNA damage responses in Saccharomyces cerevisiae.},
  author={Ana Traven and Andrew Hammet and Nora Tenis and Clyde L Denis and J{\"o}rg Heierhorst},
  journal={Genetics},
  year={2005},
  volume={169 1},
  pages={65-75}
}
DNA damage checkpoints regulate gene expression at the transcriptional and post-transcriptional level. Some components of the yeast Ccr4-Not complex, which regulates transcription as well as transcript turnover, have previously been linked to DNA damage responses, but it is unclear if this involves transcriptional or post-transcriptional functions. Here we show that CCR4 and CAF1, which together encode the major cytoplasmic mRNA deadenylase complex, have complex genetic interactions with the… CONTINUE READING

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