Ccr4-Not complex: the control freak of eukaryotic cells.

  title={Ccr4-Not complex: the control freak of eukaryotic cells.},
  author={Jason E Miller and Joseph C Reese},
  journal={Critical reviews in biochemistry and molecular biology},
  volume={47 4},
The purpose of this review is to provide an analysis of the latest developments on the functions of the carbon catabolite-repression 4-Not (Ccr4-Not) complex in regulating eukaryotic gene expression. Ccr4-Not is a nine-subunit protein complex that is conserved in sequence and function throughout the eukaryotic kingdom. Although Ccr4-Not has been studied since the 1980s, our understanding of what it does is constantly evolving. Once thought to solely regulate transcription, it is now clear that… CONTINUE READING
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