CcpC-dependent regulation of citrate synthase gene expression in Listeria monocytogenes.

@article{Mittal2009CcpCdependentRO,
  title={CcpC-dependent regulation of citrate synthase gene expression in Listeria monocytogenes.},
  author={Meghna Mittal and Silvia Picossi and Abraham L Sonenshein},
  journal={Journal of bacteriology},
  year={2009},
  volume={191 3},
  pages={
          862-72
        }
}
Citrate synthase, the first and rate-limiting enzyme of the tricarboxylic acid branch of the Krebs cycle, was shown to be required for de novo synthesis of glutamate and glutamine in Listeria monocytogenes. The citrate synthase (citZ) gene was found to be part of a complex operon with the upstream genes lmo1569 and lmo1568. The downstream isocitrate dehydrogenase (citC) gene appears to be part of the same operon as well. Two promoters were shown to drive citZ expression, a distal promoter… CONTINUE READING
BETA