CcpA-dependent carbohydrate catabolite repression regulates galactose metabolism in Streptococcus oligofermentans.

  title={CcpA-dependent carbohydrate catabolite repression regulates galactose metabolism in Streptococcus oligofermentans.},
  author={Jun Cai and Huichun Tong and Fengxia Qi and Xiuzhu Dong},
  journal={Journal of bacteriology},
  volume={194 15},
Streptococcus oligofermentans is an oral commensal that inhibits the growth of the caries pathogen Streptococcus mutans by producing copious amounts of H(2)O(2) and that grows faster than S. mutans on galactose. In this study, we identified a novel eight-gene galactose (gal) operon in S. oligofermentans that was comprised of lacABCD, lacX, and three genes encoding a galactose-specific transporter. Disruption of lacA caused more growth reduction on galactose than mutation of galK, a gene in the… CONTINUE READING
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Electrophoretic mobility shift assays demonstrated binding of CcpA to the putative catabolite response element motif in the promoter regions of the gal operon and manL , suggesting that CcpA regulates CCR through direct regulation of the transcription of the gal operon and manL. This provides the first example of oral streptococci using two parallel CcpA - dependent CCR pathways in controlling carbohydrate metabolism .
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