Cc2d1a, a C2 domain containing protein linked to nonsyndromic mental retardation, controls functional maturation of central synapses.

@article{Zhao2011Cc2d1aAC,
  title={Cc2d1a, a C2 domain containing protein linked to nonsyndromic mental retardation, controls functional maturation of central synapses.},
  author={Meng Zhao and Jesica Raingo and Zhijian J Chen and Ege T Kavalali},
  journal={Journal of neurophysiology},
  year={2011},
  volume={105 4},
  pages={1506-15}
}
Cc2d1a is an evolutionarily conserved protein composed of NH(2)-terminal Drosophila melanogaster 14 domain (DM14) domains and a COOH-terminal C2 domain. Human patients with homozygotic mutation in the gene suffer from nonsyndromic mental retardation, implying that Cc2d1a functions in the central nervous system. To examine the physiological role of the… CONTINUE READING