Cc Chemokine Receptor (Ccr)2 Is Required for Langerhans Cell Migration and Localization of T Helper Cell Type 1 (Th1)-Inducing Dendritic Cells

@article{Sato2000CcCR,
  title={Cc Chemokine Receptor (Ccr)2 Is Required for Langerhans Cell Migration and Localization of T Helper Cell Type 1 (Th1)-Inducing Dendritic Cells},
  author={Naoko Sato and Sunil K. Ahuja and Marlon P. Quinones and Vannessa K Kostecki and Robert Lee Reddick and Peter C Melby and William A. Kuziel and Seema S. Ahuja},
  journal={The Journal of Experimental Medicine},
  year={2000},
  volume={192},
  pages={205 - 218}
}
There is growing evidence that chemokines and their receptors regulate the movement and interaction of antigen-presenting cells such as dendritic cells (DCs) and T cells. We tested the hypothesis that the CC chemokine receptor (CCR)2 and CCR5 and the chemokine macrophage inflammatory protein (MIP)-1alpha, a ligand for CCR5, influence DC migration and localization. We found that deficiency of CCR2 but not CCR5 or MIP-1alpha led to distinct defects in DC biology. Langerhans cell (skin DC) density… CONTINUE READING
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Molecular cloning of a novel T cell - directed CC chemokine expressed in thymus by signal sequence trap using Epstein - Barr virus vector

  • F. Anjuere, P. Martin G. Martinez del Hoyo
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