Cbl-mediated ubiquitinylation and negative regulation of Vav.

  title={Cbl-mediated ubiquitinylation and negative regulation of Vav.},
  author={Yuko Miura-Shimura and Lei Duan and N. Ravi Shankar Mohd Lazim Abdullah Y. L. P. Thorani Rao and Alagarsamy Lakku Reddi and Hideki Shimura and Rob Rottapel and Brain J Druker and Alexander Tsygankov and Vimla Band and Hamid Band},
  journal={The Journal of biological chemistry},
  volume={278 40},
The Cbl ubiquitin ligase has emerged as a negative regulator of receptor and non-receptor tyrosine kinases. Cbl is known to associate with the proto-oncogene product Vav, a hematopoietic-restricted Rac guanine nucleotide exchange factor, but the consequences of this interaction remain to be elucidated. Using immortalized T cell lines from Cbl(+/+) and Cbl(-/-) mice, and transfection analyses in 293T cells, we demonstrate that Vav undergoes Cbl-dependent ubiquitinylation under conditions that… CONTINUE READING

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hp://w w w .jb.org/ D ow nladed from Running title: Cbl mediates Vav ubiquitinylation

  • H. Shimura, N. Hattori, +8 authors T. Suzuki
  • Nat Genet
  • 2000

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