Cbl functions downstream of Src kinases in FCγRI signaling in primary human macrophages

@article{ErdreichEpstein1999CblFD,
  title={Cbl functions downstream of Src kinases in FC$\gamma$RI signaling in primary human macrophages},
  author={Anat Erdreich-Epstein and M. Liu and Anita M. Kant and Kayvon D. Izadi and Jan A. Nolta and Donald L Durden},
  journal={Journal of Leukocyte Biology},
  year={1999},
  volume={65}
}
Cbl is a cytosolic protein that is rapidly tyrosine phosphorylated in response to Fc receptor activation and binds to the adaptor proteins Grb2, CrkL, and Nck. A few reports describe Cbl interactions in primary human hematopoietic cells. We show evidence that Cbl participates in signaling initiated by FcγRI receptor cross‐linking in human primary macrophages, and functions downstream of Src family kinases in this pathway. FcγRI stimulation in human macrophages was associated with rapid and… 

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The diverse functions of Src family kinases in macrophages.

  • C. AbramC. Lowell
  • Biology
    Frontiers in bioscience : a journal and virtual library
  • 2008
TLDR
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TLDR
The data demonstrate that the CBL-GRB2 and GRB2-SOS protein complexes are distinct and mutually exclusive in U937IF cells, supporting a model by which the C BL-GRb2 and GrB2 -SOS complexes function in separate pathways for myeloid Fc gammaRI signaling.

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TLDR
The results suggest that different adaptor proteins may have different roles in the regulation of c-cbl proto-oncogene product, andTyrosine-phosphorylated Cbl binds exclusively to the SH2 domain of Crk, another SH2/SH3 domain-containing protein, upon TCR stimulation.

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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
It is demonstrated here that the association of Fyn and c-Cbl is direct and does not require the presence of other proteins, and it is demonstrated that Fyn is the Src family kinase that preferentially interacts with c- Cbl in T cells.
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