Cbl-b is a negative regulator of inflammatory cytokines produced by IgE-activated mast cells.

@article{Gustin2006CblbIA,
  title={Cbl-b is a negative regulator of inflammatory cytokines produced by IgE-activated mast cells.},
  author={Sonja E. Gustin and Christine B. F. Thien and Wallace Y Langdon},
  journal={Journal of immunology},
  year={2006},
  volume={177 9},
  pages={5980-9}
}
c-Cbl and Cbl-b E3 ubiquitin ligases are abundantly expressed in hemopoietic cells where they negatively regulate the activity and levels of many cell surface receptors and associated signaling molecules. By comparing bone marrow-derived mast cells from c-Cbl and Cbl-b-deficient mice it has recently been shown that Cbl-b is the dominant family member for negatively regulating signaling responses from high-affinity IgE receptors. In this study, we suggest that a possible reason for the greater… CONTINUE READING

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