Cbl-b enhances Runx2 protein stability and augments osteocalcin promoter activity in osteoblastic cell lines.

@article{Salingcarnboriboon2010CblbER,
  title={Cbl-b enhances Runx2 protein stability and augments osteocalcin promoter activity in osteoblastic cell lines.},
  author={R Ampornaramveth Salingcarnboriboon and Prasit Pavasant and Mariko Noda},
  journal={Journal of cellular physiology},
  year={2010},
  volume={224 3},
  pages={743-7}
}
Cbl-b is a member of Cbl family of E3 ubiquitin (Ub) ligase. Besides the important role in ubiquitination process, other members of Cbl family have been suggested to show non-ubiquitination-related function in regulation of osteoblastic differentiation. However, the role of Cbl-b in regulation of osteoblastic function has not been known yet. To elucidate the role of Cbl-b in regulation of osteoblastic function, we examined its effects on Runx2, a master gene of osteoblastic differentiation. We… CONTINUE READING

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