Cbl-b Positively Regulates Btk-mediated Activation of Phospholipase C-γ2 in B Cells

  title={Cbl-b Positively Regulates Btk-mediated Activation of Phospholipase C-γ2 in B Cells},
  author={Tomoharu Yasuda and Tohru Tezuka and Akito Maeda and Tetsuya Inazu and Yuji Yamanashi and Hua Gu and Tomohiro Kurosaki and Tadashi Yamamoto},
  journal={The Journal of Experimental Medicine},
  pages={51 - 63}
Genetic studies have revealed that Cbl-b plays a negative role in the antigen receptor-mediated proliferation of lymphocytes. However, we show that Cbl-b-deficient DT40 B cells display reduced phospholipase C (PLC)-gamma2 activation and Ca2+ mobilization upon B cell receptor (BCR) stimulation. In addition, the overexpression of Cbl-b in WEHI-231 mouse B cells resulted in the augmentation of BCR-induced Ca2+ mobilization. Cbl-b interacted with PLC-gamma2 and helped the association of PLC-gamma2… CONTINUE READING


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