Cbl-b Deficiency in Mice Results in Exacerbation of Acute and Chronic Stages of Allergic Asthma

@inproceedings{Carson2015CblbDI,
  title={Cbl-b Deficiency in Mice Results in Exacerbation of Acute and Chronic Stages of Allergic Asthma},
  author={William F Carson and Linda A. Guernsey and Anurag Singh and Eric R. Secor and Elizabeth A. Wohlfert and Robert S B Clark and Craig M. Schramm and Steven L. Kunkel and Roger Steven Thrall},
  booktitle={Front. Immunol.},
  year={2015}
}
Mice sensitized to ovalbumin (OVA) develop allergic airway disease (AAD) with short-term daily OVA aerosol challenge; inflammation resolves with long-term OVA aerosol exposure, resulting in local inhalational tolerance (LIT). Cbl-b is an E3 ubiquitin ligase involved with CD28 signaling; Cbl-b(-/-) effector T cells are resistant to regulatory T cell-mediated suppression in vitro and in vivo. The present study utilized Cbl-b(-/-) mice to investigate the role of Cbl-b in the development of AAD and… CONTINUE READING
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