Cbfa1-dependent expression of an interferon-inducible p204 protein is required for chondrocyte differentiation

@article{Zhang2008Cbfa1dependentEO,
  title={Cbfa1-dependent expression of an interferon-inducible p204 protein is required for chondrocyte differentiation},
  author={Yu Zhang and Li Yin Kong and Cathy S Carlson and C-j Liu},
  journal={Cell Death and Differentiation},
  year={2008},
  volume={15},
  pages={1760-1771}
}
We reported earlier that an interferon-inducible p204 protein serves as a cofactor of Cbfa1 and promotes osteogenesis. Here we establish that p204 demonstrates prominent expression in growth plate chondrocytes. It is differentially expressed in the course of bone morphogenetic protein-2-triggered chondrocyte differentiation of pluripotent C3H10T1/2 cells. This expression is probably due to the activation of p204 gene by Cbfa1 and repression by Sox5 transcription factor. Cbfa1 and Sox5 bind to… CONTINUE READING

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