Cavity ring-down spectroscopy as a detector for liquid chromatography.

  title={Cavity ring-down spectroscopy as a detector for liquid chromatography.},
  author={Kate L Snyder and Richard N. Zare},
  journal={Analytical chemistry},
  volume={75 13},
We have demonstrated the use of cavity ring-down spectroscopy (CRDS) as a detector for high performance liquid chromatography (HPLC). For this use, we have designed and implemented a Brewster's angle flow cell such that cavity ring-down spectroscopy can be performed on microliter volumes of liquids. The system exhibits a linear dynamic range of 3 orders of magnitude (30 nM to 30 microM quinalizarin at 470 nm) for static measurements and 2 orders of magnitude (0.5 microM to 50 microM) for HPLC… Expand
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