Cavitation as a plausible driving force for the prebiotic formation of N9 purine nucleosides
@inproceedings{Patehebieke2021CavitationAA, title={Cavitation as a plausible driving force for the prebiotic formation of N9 purine nucleosides}, author={Yeersen Patehebieke and Ze-Run Zhao and Su-Lein Wang and Haoqing Xu and Qianqian Chen and Xiao Wang}, year={2021} }
5 Citations
A plausible prebiotic selection of ribose for RNA - formation, dynamic isolation, and nucleotide synthesis based on metal-doped-clays
- BiologyChem
- 2021
A Prebiotic Ribosylation of Pyrimidine Nucleobases Promoted by Metal Cations and Clay Minerals
- Biology
- 2021
We report a prebiotically relevant solution to the N1-ribosylation of pyrimidine nucleobases, a well-known challenge in the RNA World hypothesis. It is found that the presence of metal cations and…
A Prebiotic Ribosylation of Pyrimidine Nucleobases Enabled by Metal Cations and Clay Minerals.
- BiologyLife
- 2021
It is found that the presence of metal cations and clay minerals enable the previously unachievable direct ribosylation of uracil.
On the Origin of Sugar Handedness: Facts, Hypotheses and Missing Links-A Review
- BiologyOrigins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life
- 2022
The past and current understanding of sugar chirality in the context of prebiotic chemistry is revisited, with attention to recent developments and insights.
Hydrodynamic Cavitation: Its optimization and potential application in treatment of Pigment Industry Wastewater
- EngineeringMaterials Today: Proceedings
- 2022
References
SHOWING 1-10 OF 48 REFERENCES
Proton irradiation: a key to the challenge of N-glycosidic bond formation in a prebiotic context
- BiologyScientific Reports
- 2017
The pathway of a general reaction leading to the one-pot synthesis of ribo- and 2′-deoxy-ribonucleosides from sugars and purine nucleobases under proton irradiation in the presence of a chondrite meteorite is determined.
Spontaneous prebiotic formation of a β-ribofuranoside that self-assembles with a complementary heterocycle.
- BiologyJournal of the American Chemical Society
- 2014
A one-pot model prebiotic reaction between a pyrimidine nucleobase and ribose is reported, which produces TAP-ribose conjugates in high yield and is provided a proof-of-concept system demonstrating that several challenges associated with the prebiotics emergence of RNA, or pre-RNA polymers, may not be as problematic as widely believed.
A high-yielding, strictly regioselective prebiotic purine nucleoside formation pathway
- BiologyScience
- 2016
It is reported that the condensation of formamidopyrimidines with sugars provides the natural N-9 nucleosides with extreme regioselectivity and in good yields, providing a plausible scenario of how purineucleosides may have formed under prebiotic conditions.
Unified prebiotically plausible synthesis of pyrimidine and purine RNA ribonucleotides
- Biology, ChemistryScience
- 2019
The synthesis of the pyrimidine nucleosides from small molecules and ribose is reported, driven solely by wet-dry cycles and is compatible with purine synthesis, allowing the concurrent formation of all Watson-Crick bases.
Meteorite-catalyzed syntheses of nucleosides and of other prebiotic compounds from formamide under proton irradiation
- BiologyProceedings of the National Academy of Sciences
- 2015
In the presence of meteorites and with high-energy protons, the production of unprecedented panels of nucleobases, sugars, and, most notably, nucleosides is observed and the detection of HCN oligomers suggests the occurrence of mechanisms based on the generation of radical cyanide species (CN·) for the synthesis ofucleobases.
Prebiotic stereoselective synthesis of purine and noncanonical pyrimidine nucleotide from nucleobases and phosphorylated carbohydrates
- BiologyProceedings of the National Academy of Sciences
- 2017
It is shown that the phosphorylated ribonucleoside building blocks for RNA can be made stereoselectively under a prebiotic plausible condition with canonical and noncanonical purines, and with one non canonical pyrimidine, and that threose nucleoside phosphates can be synthesized in a similar way.
Wet-dry cycles enable the parallel origin of canonical and non-canonical nucleosides by continuous synthesis
- ChemistryNature Communications
- 2017
It is reported that geothermal fields could provide the right setup for establishing wet–dry cycles that allow for the synthesis of RNA nucleosides by continuous synthesis by simple changes of physical parameters such as temperature, pH and concentration.
Cavitation-Induced Synthesis of Biogenic Molecules on Primordial Earth
- ChemistryACS central science
- 2017
The picture that emerges from the simulations indicates that collapsing bubbles may have served as natural bioreactors in primordial oceans, producing the basic chemical ingredients required for the beginning of life.
A prebiotically plausible synthesis of pyrimidine β-ribonucleosides and their phosphate derivatives involving photoanomerization.
- Chemistry, BiologyNature chemistry
- 2017
A long-sought route through ribose aminooxazoline to the pyrimidine β-ribonucleosides and their phosphate derivatives is described that involves an extraordinarily efficient photoanomerization of α-2-thioribocytidine.
Our Odyssey to Find a Plausible Prebiotic Path to RNA: The First Twenty Years
- Biology
- 2016
Progress toward finding a plausible prebiotic synthesis of a hypothetical proto-RNA illustrates how origins research can lead to exciting and unexpected chemistries, particularly when chemical models are subjected to rigorous experimentation and regular revision in response to positive and negative results.