Cavitation-Induced Synthesis of Biogenic Molecules on Primordial Earth

  title={Cavitation-Induced Synthesis of Biogenic Molecules on Primordial Earth},
  author={Natan-Haim Kalson and David Furman and Yehuda Zeiri},
  journal={ACS Central Science},
  pages={1041 - 1049}
Despite decades of research, how life began on Earth remains one of the most challenging scientific conundrums facing modern science. It is agreed that the first step was synthesis of organic compounds essential to obtain amino acids and their polymers. Several possible scenarios that could accomplish this step, using simple inorganic molecules, have been suggested and studied over the years. The present study examines, using atomistic reactive molecular dynamics simulations, the long-standing… 
The Sonochemical Synthesis of Simple Organic Biomolecules in Aqueous Solutions Containing Dissolved Prebiotic Gases
This review considers the generation of relatively simple biomolecules, e.g., primary amino acids, resulting from the rapid collapse of bubbles in aqueous solutions containing various, low molar mass, gases, as the initiating processes for the formation of the first organic molecules on prebiotic earth and the origins of life on Earth.
Degradation Mechanism of Micro-Nanobubble Technology for Organic Pollutants in Aqueous Solutions
Micro-nanobubbles (MNBs) technology has emerged as an effective means of sewage treatment, while the molecular mechanism for its pollutant degradation is still unknown. In this paper, the reactive
Synthesis and breakdown of universal metabolic precursors promoted by iron
A purely chemical reaction network promoted by ferrous iron is described, in which aqueous pyruvate and glyoxylate build up 9 of the 11 intermediates of the biological Krebs (or tricarboxylic acid) cycle, including all 5 universal metabolic precursors.
Ejection of Glycine Molecules Adsorbed on a Water Ice Surface by Swift-heavy Ion Irradiation
Organic molecules may be adsorbed on the ice surfaces of comets or moons. We study the desorption process induced by swift-heavy ion irradiation using a molecular dynamics simulation. Focusing on the
Transforming the Accuracy and Numerical Stability of ReaxFF Reactive Force Fields.
The root cause of the unsatisfactory energy conservation is revealed, and a straightforward solution is offered that results in orders of magnitude improvement in energy conservation, numerical stability, and accuracy of ReaxFF force fields, compared to the previous state-of-the-art, at no additional cost.
A well-behaved theoretical framework for ReaxFF reactive force fields.
The previous formulation of ReaxFF was extended by alleviating additional sources of numerical instability in the original formalism by design and validated, and new functions that mitigate these limitations are designed and validated.
Organic Sonochemistry: A Chemist’s Timely Perspective on Mechanisms and Reactivity
In this Perspective, with an eye on mechanisms in particular, the potentiality of sonochemistry in synthetic organic chemistry is discussed through selected examples of past and recent developments.
Nonenzymatic Metabolic Reactions and Life's Origins.
This review discusses metabolic pathways of relevance to the origin of life in a manner accessible to chemists, and summarizes experiments suggesting several pathways might have their roots in prebiotic chemistry.


Amino acids on the rampant primordial Earth: Electric discharges and the hot salty ocean
In this work, the plausibility of one particularly important branch of prebiotic chemistry, the formation of amino acids, by electric discharge in a neutral atmosphere composed of carbon dioxide, nitrogen, and water vapour above liquid water, is investigated.
Synthesis of glycine-containing complexes in impacts of comets on early Earth.
It is shown that impact from cometary ice could possibly yield amino acids by a synthetic route independent of the pre-existing atmospheric conditions and materials on the planet.
A plausible simultaneous synthesis of amino acids and simple peptides on the primordial Earth.
Aqueous heating experiments indicate that Strecker synthesis intermediates play a key role in facilitating polymerization and highlight the potential importance of condensing reagents in generating diversity within the prebiotic chemical inventory.
From Interstellar Amino Acids to Prebiotic Catalytic Peptides: A Review
  • A. Brack
  • Biology
    Chemistry & biodiversity
  • 2007
Even if peptides are not able to self‐replicate, the accumulation of chemically active peptides on the primitive Earth appears plausible via thermostable and stereoselective β‐sheets made of alternating sequences.
Amino-acid synthesis in aqueous media under ultrasonic irradiation
The now-famous “Miller-Urey experiment” used a reduced mixture of gases to form basic organic molecules, such as amino acids. Since then, several methods have tried to reproduce the synthesis of
A production of amino acids under possible primitive earth conditions.
In this study, an apparatus was built to circulate CHI4, NH3, H2O, and H2 past an electric discharge, and the resulting mixture has been tested for amino acids by paper chromatography.
Glycine and alanine synthesis from formaldehyde and hydroxylamine in the field of ultrasound waves
Essential biological substances like formaldehyde, ammonia, hydrocyanic acid, and amino acids compounds similar to carbohydrates by their properties were synthesized in the field of ultrasound waves in model experiments.
Miller experiments in atomistic computer simulations
It is shown that glycine spontaneously forms from mixtures of simple molecules once an electric field is switched on and formic acid and formamide are identified as key intermediate products of the early steps of the Miller reactions, and the crucible of formation of complex biological molecules.