Cavernosal Alpha-Blockade: A New Technique for Investigating and Treating Erectile Impotence

  title={Cavernosal Alpha-Blockade: A New Technique for Investigating and Treating Erectile Impotence},
  author={Giles Skey Brindley},
  journal={British Journal of Psychiatry},
  pages={332 - 337}
  • G. Brindley
  • Published 1 October 1983
  • Medicine
  • British Journal of Psychiatry
Summary Intracavernosal injection of phenoxybenzamine, in a dose too small to have significant general effects, caused full erection lasting between half an hour and 30 hours in 3 of 4 potent men (2 normal, 2 anorgasmic) and in 6 of 11 impotent men. In the remaining potent man and 3 of the remaining impotent it caused the penis to be stiff enough for intromission. Six of the eleven impotent men have had sexual intercourse, for the first time for months or years, while under the drug. The… 

Treatment of Erectile Impotence by Intracavernosal Injection of Drugs that Relax Smooth Muscle

Two smooth muscle relaxants are now in use for the treatment of erectile impotence and both are effective, but their safety for long- term use cannot be firmly established until many years have elapsed.

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Intracavernosal Papaverine and Phentolamine for the Medical Management of Erectile Dysfunction in a Genitourinary Clinic

It is concluded that intracavernous papaverine and phentolamine is an effective therapy for erectile failure in a genitourinary clinic.

Prolonged erections following intracorporeal injection of medications to overcome impotence.

The management of 17 men who developed prolonged erections following the intracorporeal injection of vasoactive drugs (e.g. papaverine) for the treatment of erectile dysfunction and the aspiration of 20 to 50 ml of blood from the penis is an effective treatment of this complication.

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Current perspectives on intracavernosal pharmacotherapy for erectile dysfunction

  • H. Porst
  • Medicine
    International Journal of Impotence Research
  • 2000
A historical and current perspective on intracavernosal therapy is provided and the popular injectable therapeutic agents that are currently used for the treatment of ED are reviewed.

Biweekly intracavernous administration of papaverine for erectile dysfunction.

It is concluded that administering papaverine intracavernosally every 2 weeks improves sexual potency in a subset of sexually impotent patients.



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A placebo-controlled double-blind study of the effect of phenoxybenzamine in benign prostatic obstruction.

A double-blind placebo-controlled study of phenoxybenzamine for the symptomatic treatment of benign prostatic obstruction concluded that there was good evidence that the treatment is effective.


Alpha‐adrenergic blockers in prostatism

Thirty patients awaiting prostatectomy with no history of cardiovascular disease were selected for a trial of alpha‐adrenergic blocking agents and 18 found their symptoms were improved and 10 showed urodynamic improvement.

5E5 8AF (Received 15 February; revised

  • 1983