Caveolins in cardioprotection - translatability and mechanisms.

  title={Caveolins in cardioprotection - translatability and mechanisms.},
  author={Jan M. Schilling and David M Roth and Hemal H Patel},
  journal={British journal of pharmacology},
  volume={172 8},
Translation of preclinical treatments for ischaemia-reperfusion injury into clinical therapies has been limited by a number of factors. This review will focus on a single mode of cardiac protection related to a membrane scaffolding protein, caveolin, which regulates protective signalling as well as myocyte ultrastructure in the setting of ischaemic stress. Factors that have limited the clinical translation of protection will be considered specifically in terms of signalling and structural… CONTINUE READING