• Biology, Medicine
  • Published in Journal of cell science 2000

Caveolin proteins in signaling, oncogenic transformation and muscular dystrophy.

@article{Razani2000CaveolinPI,
  title={Caveolin proteins in signaling, oncogenic transformation and muscular dystrophy.},
  author={Babak Razani and Anja Schlegel and Michael p. Lisanti},
  journal={Journal of cell science},
  year={2000},
  volume={113 ( Pt 12)},
  pages={
          2103-9
        }
}
In adult animals and humans, signal transduction maintains homeostasis. When homeostatic mechanisms are interrupted, an illness or disease may ensue. Caveolae are plasma membrane specializations that contain the structural proteins caveolins, and appear to be important for normal signal transduction. The caveolin scaffolding domain interacts with several signaling molecules, sequestering them in the absence of activating signals, and thereby reducing the signal-to-noise ratio. Deletion and… CONTINUE READING

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