Caveolin limits membrane microdomain mobility and integrin-mediated uptake of fibronectin-binding pathogens.

@article{Hoffmann2010CaveolinLM,
  title={Caveolin limits membrane microdomain mobility and integrin-mediated uptake of fibronectin-binding pathogens.},
  author={Christine Hoffmann and Anne D. Berking and Franziska Agerer and Alexander Buntru and Florian Neske and Gursharan Singh Chhatwal and Knut Ohlsen and Christof R. Hauck},
  journal={Journal of cell science},
  year={2010},
  volume={123 Pt 24},
  pages={4280-91}
}
Staphylococcus aureus, which is a leading cause of hospital-acquired infections, binds via fibronectin to integrin α5β1, a process that can promote host colonization in vivo. Integrin engagement induces actin cytoskeleton rearrangements that result in the uptake of S. aureus by non-professional phagocytic cells. Interestingly, we found that fibronectin-binding S. aureus trigger the redistribution of membrane microdomain components. In particular, ganglioside GM1 and GPI-linked proteins were… CONTINUE READING

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