Caveolin Transfection Results in Caveolae Formation but Not Apical Sorting of Glycosylphosphatidylinositol (GPI)-anchored Proteins in Epithelial Cells

@article{Lipardi1998CaveolinTR,
  title={Caveolin Transfection Results in Caveolae Formation but Not Apical Sorting of Glycosylphosphatidylinositol (GPI)-anchored  Proteins in Epithelial Cells },
  author={Concetta Lipardi and Rosalia C Mora and Veronica Colomer and Simona Paladino and Lucio Nitsch and Enrique Rodriguez-Boulan and Chiara Zurzolo},
  journal={The Journal of Cell Biology},
  year={1998},
  volume={140},
  pages={617 - 626}
}
Most epithelial cells sort glycosylphosphatidylinositol (GPI)-anchored proteins to the apical surface. The "raft" hypothesis, based on data mainly obtained in the prototype cell line MDCK, postulates that apical sorting depends on the incorporation of apical proteins into cholesterol/glycosphingolipid (GSL) rafts, rich in the cholesterol binding protein caveolin/VIP21, in the Golgi apparatus. Fischer rat thyroid (FRT) cells constitute an ideal model to test this hypothesis, since they missort… CONTINUE READING
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