Caveolin-1 tyrosine phosphorylation enhances paclitaxel-mediated cytotoxicity.

@article{Shajahan2007Caveolin1TP,
  title={Caveolin-1 tyrosine phosphorylation enhances paclitaxel-mediated cytotoxicity.},
  author={Ayesha N. Shajahan and Aifen Wang and Markus Decker and Richard D Minshall and Minetta C. Liu and Robert Clarke},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 8},
  pages={5934-43}
}
Caveolin-1 (CAV1), a highly conserved membrane-associated protein, is a putative regulator of cellular transformation. CAV1 is localized in the plasmalemma, secretory vesicles, Golgi, mitochondria, and endoplasmic reticulum membrane and associates with the microtubule cytoskeleton. Taxanes such as paclitaxel (Taxol) are potent anti-tumor agents that repress the dynamic instability of microtubules and arrest cells in the G(2)/M phase. Src phosphorylation of Tyr-14 on CAV1 regulates its cellular… CONTINUE READING

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