Caveolin-1 regulates glioblastoma aggressiveness through the control of alpha(5)beta(1) integrin expression and modulates glioblastoma responsiveness to SJ749, an alpha(5)beta(1) integrin antagonist.

@article{Martin2009Caveolin1RG,
  title={Caveolin-1 regulates glioblastoma aggressiveness through the control of alpha(5)beta(1) integrin expression and modulates glioblastoma responsiveness to SJ749, an alpha(5)beta(1) integrin antagonist.},
  author={Sophie G. Martin and Erika C Cosset and J{\'e}r{\^o}me Terrand and Anne Maglott and Kazuki Takeda and Monique Dontenwill},
  journal={Biochimica et biophysica acta},
  year={2009},
  volume={1793 2},
  pages={354-67}
}
Caveolin-1 plays a checkpoint function in the regulation of processes often altered in cancer. Although increased expression of caveolin-1 seems to be the norm in the glioma family of malignancies, populations of caveolin-1 positive and negative cells coexist among glioblastoma specimens. As no data are available to date on the contribution of such cells to the phenotype of glioblastoma, we manipulated caveolin-1 in the glioblastoma cell line U87MG. We showed that caveolin-1 plays a critical… CONTINUE READING
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