Caveolin-1 regulates Mcl-1 stability and anoikis in lung carcinoma cells.

  title={Caveolin-1 regulates Mcl-1 stability and anoikis in lung carcinoma cells.},
  author={Preedakorn Chunhacha and Varisa Pongrakhananon and Yon Rojanasakul and Pithi Chanvorachote},
  journal={American journal of physiology. Cell physiology},
  volume={302 9},
Both caveolin-1 (Cav-1) and Mcl-1 have been implicated in the regulation of cancer cell anoikis, but their relationship and underlying mechanisms of regulation are not known. The present study demonstrated for the first time that Cav-1 regulates Mcl-1 through protein-protein interaction and inhibits its downregulation during cell anoikis in human lung cancer cells. Immunoprecipitation and immunocytochemistry studies showed that Cav-1 interacted with Mcl-1 and prevented it from degradation via… CONTINUE READING
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