Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities.

@article{Razani2001Caveolin1NM,
  title={Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities.},
  author={Babak Razani and Jeffery A Engelman and Xiao Bo Wang and William Schubert and Xiao Liang Zhang and Carolyn B. Marks and Frank M Macaluso and R. Graham G. Russell and Maoxiang Li and Richard G. Pestell and Dolores Di Vizio and Hai Hou and Burkhard Kneitz and Guy Lagaud and George J. Christ and Winfried Edelmann and Michael Phillip Lisanti},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 41},
  pages={38121-38}
}
Caveolin-1 is the principal structural protein of caveolae membranes in fibroblasts and endothelia. Recently, we have shown that the human CAV-1 gene is localized to a suspected tumor suppressor locus, and mutations in Cav-1 have been implicated in human cancer. Here, we created a caveolin-1 null (CAV-1 -/-) mouse model, using standard homologous recombination techniques, to assess the role of caveolin-1 in caveolae biogenesis, endocytosis, cell proliferation, and endothelial nitric-oxide… CONTINUE READING
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