Caveolin-1-negative head and neck squamous cell carcinoma primary tumors display increased epithelial to mesenchymal transition and prometastatic properties.

@article{Jung2015Caveolin1negativeHA,
  title={Caveolin-1-negative head and neck squamous cell carcinoma primary tumors display increased epithelial to mesenchymal transition and prometastatic properties.},
  author={Alain Jung and Anne-Marie Le Ray and Ludivine Ramolu and Christine Macabre and Florian Simon and Fanny Noulet and A F Blandin and Guillaume Renner and Maxime M-A Lehmann and Laurence Choulier and Horst Kessler and Joseph Abecassis and Monique Dontenwill and Sophie G. Martin},
  journal={Oncotarget},
  year={2015},
  volume={6 39},
  pages={41884-901}
}
Distant metastases arise in 20-30% of patients with squamous cell carcinoma of the head and neck (HNSCC) in the 2 years following treatment. Therapeutic options are limited and the outcome of the patients is poor. The identification of predictive biomarkers of patient at risk for distant metastasis and therapies are urgently needed. We previously identified a clinical subgroup, called "R1" characterized by high propensity for rapid distant metastasis. Here, we showed that "R1" patients do not… CONTINUE READING

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