Caveolin-1 modulates the activity of the volume-regulated chloride channel.

  title={Caveolin-1 modulates the activity of the volume-regulated chloride channel.},
  author={Dominique Trouet and Bernd Nilius and Allan Jacobs and Claude A Remacle and Guy Droogmans and Jan Eggermont},
  journal={The Journal of physiology},
  volume={520 Pt 1},
1. Caveolae are small invaginations of the plasma membrane that have recently been implicated in signal transduction. In the present study, we have investigated whether caveolins, the principal protein of caveolae, also modulate volume-regulated anion channels (VRACs). 2. ICl,swell, the cell swelling-induced chloride current through VRACs, was studied in three caveolin-1-deficient cell lines: Caco-2, MCF-7 and T47D. 3. Electrophysiological measurements showed that ICl, swell was very small in… CONTINUE READING