Caveolin-1 modulates intraocular pressure: implications for caveolae mechanoprotection in glaucoma

@inproceedings{Elliott2016Caveolin1MI,
  title={Caveolin-1 modulates intraocular pressure: implications for caveolae mechanoprotection in glaucoma},
  author={Michael H. Elliott and Nicole E. Ashpole and Xiaowu Gu and Leonie Herrnberger and Mark E. McClellan and Gina L. Griffith and Alaina M. Reagan and Timothy M. Boyce and Masaki Tanito and Ernst R Tamm and William Daniel Stamer},
  booktitle={Scientific reports},
  year={2016}
}
Polymorphisms in the CAV1/2 genes that encode signature proteins of caveolae are associated with glaucoma, the second leading cause of blindness worldwide, and with its major risk factor, intraocular pressure (IOP). We hypothesized that caveolin-1 (Cav-1) participates in IOP maintenance via modulation of aqueous humor drainage from the eye. We localize caveolae proteins to human and murine conventional drainage tissues and show that caveolae respond to mechanical stimulation. We show that Cav-1… CONTINUE READING