Caveolin-1 mediated radioresistance of 3D grown pancreatic cancer cells.

Abstract

BACKGROUND AND PURPOSE Resistance of pancreatic ductal adenocarcinoma (PDAC) to chemo- and radiotherapy is a major obstacle. The integral membrane protein Caveolin-1 (Cav-1) has been suggested as a potent target in human pancreatic carcinoma cells. MATERIALS AND METHODS Human pancreatic tumor cells were examined in a three-dimensional (3D) cell culture… (More)
DOI: 10.1016/j.radonc.2009.07.004

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