Caveolin-1 knockout mice have increased bone size and stiffness.

  title={Caveolin-1 knockout mice have increased bone size and stiffness.},
  author={Janet E. Rubin and Zvi Schwartz and Barbara D Boyan and Xian Fan and Natasha D Case and Buer Sen and Marcus Drab and Deborah Elaine Smith and Mar{\'i}a Alem{\'a}n and Kevin L Wong and Hai Dong Yao and Hanjoong Jo and Ted S. Gross},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  volume={22 9},
UNLABELLED The skeletal phenotype of the cav-1(-/-) mouse, which lacks caveolae, was examined. muCT and histology showed increased trabecular and cortical bone caused by the gene deletion. Structural changes were accompanied by increased mechanical properties. Cell studies showed that cav-1 deficiency leads to increased osteoblast differentiation. These results suggest that cav-1 helps to maintain osteoblast progenitors in a less differentiated state. INTRODUCTION The absence of caveolin-1 in… CONTINUE READING
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