Caveolin-1 knockout mice exhibit impaired induction of mGluR-dependent long-term depression at CA3-CA1 synapses.

@article{Takayasu2010Caveolin1KM,
  title={Caveolin-1 knockout mice exhibit impaired induction of mGluR-dependent long-term depression at CA3-CA1 synapses.},
  author={Yukihiro Takayasu and Koichi Takeuchi and Ranju Kumari and Michael V. L. Bennett and R Suzanne Zukin and Anna Francesconi},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 50},
  pages={21778-83}
}
Group I metabotropic glutamate receptors (mGluR1/5) are important to synaptic circuitry formation during development and to forms of activity-dependent synaptic plasticity. Dysregulation of mGluR1/5 signaling is implicated in some disorders of neurodevelopment, including fragile X syndrome, the most common inherited form of intellectual disabilities and leading cause of autism. Site(s) in the intracellular loops of mGluR1/5 directly bind caveolin-1, an adaptor protein that associates with… CONTINUE READING

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