Caveolin-1 is necessary for hepatic oxidative lipid metabolism: evidence for crosstalk between caveolin-1 and bile acid signaling.

@article{FernndezRojo2013Caveolin1IN,
  title={Caveolin-1 is necessary for hepatic oxidative lipid metabolism: evidence for crosstalk between caveolin-1 and bile acid signaling.},
  author={Manuel Alejandro Fern{\'a}ndez-Rojo and M. Milena Gongora and Rebecca L. Fitzsimmons and Nick Martel and Sheree D. Martin and Susan J. Nixon and Andrew J. Brooks and Maria P Ikonomopoulou and Sally Martin and Harriet P. Lo and Stephen Myers and Christina M. Restall and Charles Ferguson and Paul F Pilch and Sean L McGee and Robin L Anderson and Michael J. Waters and John F Hancock and Sean M. Grimmond and George E. O. Muscat and Robert G. Parton},
  journal={Cell reports},
  year={2013},
  volume={4 2},
  pages={238-47}
}
Caveolae and caveolin-1 (CAV1) have been linked to several cellular functions. However, a model explaining their roles in mammalian tissues in vivo is lacking. Unbiased expression profiling in several tissues and cell types identified lipid metabolism as the main target affected by CAV1 deficiency. CAV1-/- mice exhibited impaired hepatic peroxisome proliferator-activated receptor α (PPARα)-dependent oxidative fatty acid metabolism and ketogenesis. Similar results were recapitulated in CAV1… CONTINUE READING
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Fatty acid regulation of hepatic lipid metabolism.

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