Caveolin-1 is essential for activation of Rac1 and NAD(P)H oxidase after angiotensin II type 1 receptor stimulation in vascular smooth muscle cells: role in redox signaling and vascular hypertrophy.

@article{Zuo2005Caveolin1IE,
  title={Caveolin-1 is essential for activation of Rac1 and NAD(P)H oxidase after angiotensin II type 1 receptor stimulation in vascular smooth muscle cells: role in redox signaling and vascular hypertrophy.},
  author={Lian Zuo and Masuko Ushio-Fukai and Satoshi Ikeda and Lula L. Hilenski and Nikolay A. Patrushev and Robert W. Alexander},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2005},
  volume={25 9},
  pages={1824-30}
}
OBJECTIVE Angiotensin II (Ang II) is a potent mediator of vascular hypertrophy in vascular smooth muscle cells (VSMCs). These effects are mediated through the Ang II type 1 receptor (AT1R) and require its trafficking through caveolin-1 (Cav1)-enriched lipid rafts and reactive oxygen species (ROS) derived from Rac1-dependent NAD(P)H oxidase. The specific role(s) of Cav1 in AT1R signaling is incompletely understood. METHODS AND RESULTS Knockdown of Cav1 protein by small interfering RNA (siRNA… CONTINUE READING
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