Caveolin-1 gene silencing promotes the activation of PI3K/AKT dependent on Erα36 and the transformation of MCF10ACE

@article{Feng2010Caveolin1GS,
  title={Caveolin-1 gene silencing promotes the activation of PI3K/AKT dependent on Erα36 and the transformation of MCF10ACE},
  author={Shuang Feng and Yang Wang and Xi Wang and Zhaoyi Wang and Yuying Cui and Jing Liu and Chunhui Zhao and Mei Jin and Wei Guo Zou},
  journal={Science China Life Sciences},
  year={2010},
  volume={53},
  pages={598-605}
}
ERα36, a variant of estrogen receptor-α, acts as a dominant-negative factor in both estrogen-dependent and estrogenindependent transactivation signaling pathways, and is a key factor in the promotion, progression and prognosis of breast cancers. Caveolin-1, a 22- to 24-kD integral membrane protein, may function as a tumor suppressor in inhibiting of many growth-promoting signaling pathways. It was shown that downregulation of Caveolin-1 strengthens the interaction of ERα and Caveolin-1. In… CONTINUE READING
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