Caveolin-1 expression negatively regulates cell cycle progression by inducing G(0)/G(1) arrest via a p53/p21(WAF1/Cip1)-dependent mechanism.

@article{Galbiati2001Caveolin1EN,
  title={Caveolin-1 expression negatively regulates cell cycle progression by inducing G(0)/G(1) arrest via a p53/p21(WAF1/Cip1)-dependent mechanism.},
  author={Ferruccio Galbiati and Daniela Volont{\'e} and Jingjing Liu and Franco Capozza and Philippe G Frank and Liping Zhu and Richard G. Pestell and Michael Phillip Lisanti},
  journal={Molecular biology of the cell},
  year={2001},
  volume={12 8},
  pages={
          2229-44
        }
}
Caveolin-1 is a principal component of caveolae membranes in vivo. Caveolin-1 mRNA and protein expression are lost or reduced during cell transformation by activated oncogenes. Interestingly, the human caveolin-1 gene is localized to a suspected tumor suppressor locus (7q31.1). However, it remains unknown whether caveolin-1 plays any role in regulating cell cycle progression. Here, we directly demonstrate that caveolin-1 expression arrests cells in the G(0)/G(1) phase of the cell cycle. We show… CONTINUE READING
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