Caveolin-1 expression is significantly associated with drug resistance and poor prognosis in advanced non-small cell lung cancer patients treated with gemcitabine-based chemotherapy.

@article{Ho2008Caveolin1EI,
  title={Caveolin-1 expression is significantly associated with drug resistance and poor prognosis in advanced non-small cell lung cancer patients treated with gemcitabine-based chemotherapy.},
  author={Chao-Chi Ho and Sung-Hsin Kuo and Pei-Hsin Huang and Hsin-Yi Huang and C J Yang and Pan-Chyr Yang},
  journal={Lung cancer},
  year={2008},
  volume={59 1},
  pages={105-10}
}
Caveolin-1 was up-regulated in different drug-resistant cancer cell lines and was suggested to confer drug resistance by different mechanisms. However, the relation of caveolin-1 expression and the clinical response to chemotherapy and prognosis in non-small cell lung cancer (NSCLC) remains unknown. Total 73 NSCLC (stages IIIB and IV) patients who received gemcitabine-based chemotherapy and also had tumour specimens available before treatment were assessed for caveolin-1 expression using… CONTINUE READING

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