Caveolin-1-deficient mice show insulin resistance and defective insulin receptor protein expression in adipose tissue.

@article{Cohen2003Caveolin1deficientMS,
  title={Caveolin-1-deficient mice show insulin resistance and defective insulin receptor protein expression in adipose tissue.},
  author={Alex W. Cohen and Babak Razani and Xiao Bo Wang and Terry P. Combs and Terence M. Williams and Phillip E Scherer and Michael Phillip Lisanti},
  journal={American journal of physiology. Cell physiology},
  year={2003},
  volume={285 1},
  pages={C222-35}
}
Several lines of evidence suggest that a functional relationship exists between caveolin-1 and insulin signaling. However, it remains unknown whether caveolin-1 is normally required for proper insulin receptor signaling in vivo. To address this issue, we examined the status of insulin receptor signaling in caveolin-1 (-/-)-deficient (Cav-1 null) mice. Here, we show that Cav-1 null mice placed on a high-fat diet for 9 mo develop postprandial hyperinsulinemia. An insulin tolerance test (ITT… CONTINUE READING
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CAVEOLIN-1 AND INSULIN RESISTANCE AJP-Cell Physiol

  • B Razani, XB Wang, +7 authors W Edelmann
  • Jne 21,
  • 2003
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